Natural product-like combinatorial libraries
نویسندگان
چکیده
منابع مشابه
Natural Product-Like Combinatorial Libraries
A química combinatorial emergiu ao longo dos últimos anos como uma importante ferramenta na pesquisa de moléculas pioneiras para a modelagem de novos fármacos. Nesta perspectiva, a diversidade estrutural e a vasta gama de propriedades biológicas exibidas pelos metabolitos secundários, constituem um desafio à implementação de estratégias combinatórias na síntese e derivatização de produtos natur...
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An important aim in biology research is the elucidation of the role of proteins in complex, dynamic biological systems through the selective perturbation of their function. In contrast to genetic perturbations, chemical perturbations of protein function are conditional, acute, easily tuneable and reversible. [1] Furthermore, drug development still largely depends on the availability of bioactiv...
متن کاملNatural product libraries: assembly, maintenance, and screening.
This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along with methods for generating a fractionated sub-library. The best methods to store, maintain and prepare the library for screening are addressed...
متن کاملIntegrating natural product synthesis and combinatorial chemistry*,†
The fields of natural product total synthesis and combinatorial chemistry have major differences as well as much in common. Unique to combinatorial chemistry is the need to devise rapid and efficient methods for parallel synthesis and purification, while an area of overlap is the targeting of natural product scaffolds for combinatorial libraries. Both these aspects are illustrated with examples...
متن کاملAdvances in solution- and solid-phase synthesis toward the generation of natural product-like libraries.
4.1. Aeruginosin 298-A 2002 4.2. Bleomycin 2003 4.3. Clavulones 2004 4.4. Curacin A 2005 4.5. Dysidiolide 2006 4.6. Epothilone 2006 4.7. Erythromycin A 2007 4.8. Estrone 2008 4.9. Fellutamide 2009 4.10. Fumiquinazoline 2010 4.11. Gougerotin 2010 4.12. Homocamptothecin 2010 4.13. Illudin 2011 4.14. Macrosphelide 2012 4.15. Mappicine 2012 4.16. Mniopetals and Marasmanes 2013 4.17. Murisolin 2014 ...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2003
ISSN: 0103-5053
DOI: 10.1590/s0103-50532003000500002